Images scientifiques
<p>Basophils are rarely seen in peripheral blood of guinea pigs. They are only slightly larger than heterophils, have a lobulated homogeneously purple-staining nucleus and numerous round violet granules of varying size.</p>
<p>Bone marrow smear of a guinea pig showing (left to right) a basophil, plasma cell, polychromatic erythroblast as well as a monocyte with greyish cytoplasm centre down and a heterophil below.</p>
<p>Eosinophils of guinea pigs are larger than heterophils, with a less segmented nucleus and thick, round, bright red granules that almost completely fill the cytoplasm. </p>
<p>Eosinophil to the left, adjacent to the right a neutrophil with a condensed, segmented nucleus with up to five or more segments and small eosinophilic granules in the cytoplasm, therefore also termed heterophil or pseudoeosinophil. Eosinophils are larger than heterophils and have thick, round, bright red granules that almost completely fill the cytoplasm.</p>
<p>Mononuclear leucocyte containing an inclusion body composed of glycoprotein, a so called Kurloff body. Foa-Kurloff or simply Kurloff cells are unique to the guinea pig and account for up to 4% of the differential leukocyte count. They are reported to have NK cell activity. </p>
<p>A hypersegmented neutrophil (heterophil) with nuclear filaments linking the segments.</p>
<p>Kurloff cells (KC) are unique to the guinea pig and account for up to 4% of the differential leukocyte </p> <p>count. The KC cell is a specialized mononuclear leukocyte that contains an intracytoplasmic, finely </p> <p>granular to fibrillar inclusion body consisting of a mucopolysaccharide. The exact origin and function of these cells is unknown, although it has been speculated that they have killer cell activity. </p>
<p>A small lymphocyte with a round to oval, condensed nucleus surrounded by a narrow band of cytoplasm. The neutrophil is hypersegmented, something that is frequently found in guinea pigs. Due to the reddish staining granules this cell is also called heterophil in this species. </p>
<p>Although the cell to the left has a concave nucleus, its cytoplasm and uniformly staining nuclear chromatin is characteristic for a lymphocyte. The cell to the right is a typical lymphocyte of a guinea pig.</p>